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SS-31 (Elamipretide): the mitochondria-targeting peptide in recent studies

Research summary. Everything below describes published research on SS-31 (elamipretide) as a compound. Nothing here is advice, and no outcome, benefit or dose is implied for any person. Products are supplied for laboratory research use only, not for human consumption.

SS-31, also known as elamipretide, is a mitochondria-targeting research peptide. It concentrates at the inner mitochondrial membrane, which is why it appears so often in cellular-ageing and mitochondrial-function research. Two lab studies published in mid-2026 looked at it in heart cells.

Radiation-driven cell ageing

In July 2026, researchers exposed heart muscle cells (a rat cell line plus human stem-cell-derived cardiomyocytes) to gamma radiation (Journal of Radiation Research).

They reported that SS-31 lowered markers of cell ageing, including the senescence proteins p16 and p21, reduced inflammatory cytokines, cut mitochondrial reactive oxygen species and normalised mitochondrial respiration. This is a lab dish study, not an animal or human trial.

An honest limit from a companion study

A companion study from an overlapping group used the chemotherapy drug doxorubicin to age rat heart cells (Biology, June 2026). Researchers reported SS-31 eased several of the same ageing markers, but did not undo the drug-induced cell-cycle arrest. It is a useful, honest counterpoint, the peptide did not reverse everything.

The compound at Revexa

Related mitochondrial-research compounds in the catalogue include MOTS-c 10mg and NAD+.

All products at Revexa are supplied strictly for laboratory and research use only. Not for human or veterinary use, and not for consumption. The research described above is reported as published, in the cell models the original authors studied, and must not be read as a claim, benefit or instruction for any individual.

 
 
 

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